Regeneration is the ability of the body to regrow tissue when it is lost by trauma, disease, or other misadventure. The most famous example of this is the salamander, which can reproduce whole arms, legs, tails, and other body parts within days following their amputation.
Salamanders are, however, not the only creatures with such powers - humans have them naturally as well (at least for a time) while developing in the womb. If a developing baby loses a finger or another of its extremities, it simply grows it back without forming scar tissue.
Indeed, very young neonatal babies can sometimes do the same if injured shortly after being born. Even in adults, kidneys and livers retain some of this regenerative capacity when they are damaged.
Foregen was brought into existence by its founders’ desire to harness regenerative medicine’s amazing advances over the last twenty years. Under certain circumstances, tissue engineering techniques can now restore original tissue to those who have lost it.
This 90-second video by Lyrical Science offers an explanation in layman’s terms of the process of tissue engineering and regenerative medicine - for a more complete review on the science of regeneration, follow the links that are embedded throughout this page.
Regenerative medicine has accomplished feats unimaginable just a decade ago. Such scientific progress demonstrates that Foregen’s mission to regenerate foreskins and reverse circumcision is possible. In fact, Foregen has made tangible progress towards foreskin regeneration.
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We believe so. In other regenerative surgeries, the new tissue reintegrates itself into the body, which recognizes the tissue as its own and does not reject it via the immune system as it would for grafted skin or transplanted organs.
Those who have already undergone regenerative therapies have had amazing success. For example, those who have received regenerated bladders or tracheas, as mentioned earlier, now have fully functioning organs!
The nerve connections severed by the trauma of the surgery (in our case, circumcision) were reconnected to the body with the new implanted tissue. We expect Foregen to achieve similar results in our clinical trial.
We at Foregen appreciate your willingness to help us in our mission to apply state-of-the-art regenerative therapies to you or a loved one’s most intimate organ. We are moving as fast as we can, but to stay up to date with all of our advancements, please sign up for our newsletter.
Also, we appreciate your tax deductible donations which fund our continued research. Lastly, please share Foregen with your friends and family and over social media to help spread the word. By helping Foregen, you bring foreskin regeneration one step closer to becoming a reality.
Very soon, we hope! We already have the ECM from decellularizing animal foreskins. The next step of our work, decellularizing human foreskin tissue, was published in a peer reviewed research paper in SAGE Journal of Tissue Engineering, with very promising results.
This step was very important for creating a viable ECM that maintains the structures of the foreskin for regeneration. This was a success and enables us to move on to our next phase, which will be to conduct a preclinical trial with an animal model to test for biocompatibility.
In the short term, we hope to fully regenerate these human foreskins. Once we have accomplished that, our goal is to advance onto human clinical trials as soon as it is safe to do so.
